Inspiration and composition

This acrylic triptych delves into the process of amyloid fibril formation—aggregates of misfolded proteins that play a pivotal role in neurodegenerative diseases. The left panel depicts fibrils as they appear in diseased states (fluorescent orange), while the right panel shows protein condensates (fluorescent green), small drops hypothesized to play a role in fibril formation. The central panel depicts the meeting of both states, a process we do not understand. Thus, it remains abstract, inviting viewers to explore the mysteries bridging these states. 

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Rüdiger chose ultramarine blue as the foundational colour for its aesthetic appeal and its ability to create striking contrast with the fluorescent orange and green hues. The layered background, created using stamping and textured paste techniques, adds depth and dimension, while the fluorescent colours highlight key molecular features in an abstract way. For the first time in his work, Rüdiger extended elements of the design onto the triptych’s frames, reflecting the continuous and interconnected nature of the phenomena he studies​​. 

Stefan Rüdiger is a professor of Protein Chemistry of Disease at Utrecht University. His group investigates the molecular processes underpinning neurodegenerative diseases such as Alzheimer’s and Parkinson’s. With a background in biochemistry and structural biology, Rüdiger’s work bridges the realms of molecular action and disease pathology. Beyond his academic achievements, Rüdiger has cultivated a passion for painting, creating art pieces for cover art or as unique gifts for co-workers or colleagues to commemorate major milestones. This practice reflects his belief in the intersection of science and creativity and his dedication to fostering both within his laboratory community.